IV Therapy · Anti-Aging
If there is one molecule that sits at the intersection of energy production, DNA repair, cellular aging, and metabolic health, it is NAD+ — nicotinamide adenine dinucleotide. Every cell in your body uses it. Without it, mitochondria shut down, DNA damage accumulates unchecked, and the sirtuins — proteins that regulate longevity and stress response — go quiet. And by the time you reach 40, your NAD+ levels are roughly half of what they were at 20.
This decline is not trivial. Researchers studying aging now widely consider NAD+ depletion to be one of the primary drivers of age-related deterioration — not just a symptom of aging, but a cause. Restoring NAD+ levels is one of the most direct ways to intervene in the biology of aging.
NAD+ serves as a coenzyme in hundreds of metabolic reactions, but its most critical roles fall into four categories:
NAD+ is an essential electron carrier in the mitochondrial electron transport chain — the process by which your cells convert nutrients into ATP, the energy currency your body runs on. When NAD+ levels are low, this process becomes inefficient. You feel it as fatigue, brain fog, reduced physical output, and slow recovery. Restoring NAD+ directly improves mitochondrial function and ATP output.
PARP enzymes (poly-ADP ribose polymerases) are the primary responders when DNA is damaged — by UV radiation, oxidative stress, or normal replication errors. PARP enzymes require NAD+ as a substrate. When NAD+ is depleted, PARP activity drops and DNA damage accumulates. This is a direct pathway from NAD+ decline to genomic instability — one of the hallmarks of aging and cancer development.
Sirtuins are a family of proteins with powerful effects on longevity, metabolic regulation, inflammation, and stress response. They require NAD+ to function. Sirtuin 1 (SIRT1), activated by NAD+, promotes mitochondrial biogenesis, reduces inflammation, and has been linked to extended lifespan in multiple research models. Sirtuin 3 (SIRT3) protects mitochondrial function and reduces oxidative stress. When NAD+ drops, sirtuin activity drops with it — and these protective, longevity-promoting processes slow down.
NAD+ biosynthesis fluctuates with your circadian clock, and conversely, NAD+ levels affect clock gene expression. Low NAD+ is associated with circadian rhythm disruption — which manifests as poor sleep quality, metabolic dysregulation, and accelerated aging. Many clients receiving NAD+ IV therapy report significant improvements in sleep depth and consistency within days of their infusion.
The supplement market has responded to the NAD+ research with NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) — NAD+ precursors that, in theory, your cells convert into NAD+. These supplements have genuine effects and can modestly raise NAD+ levels. The problem is efficiency.
"Oral NAD+ precursors raise plasma levels of precursors, but intracellular NAD+ restoration — particularly in metabolically active tissues like muscle and brain — requires concentrations that oral delivery simply cannot reliably achieve."
IV NAD+ therapy bypasses the digestive system entirely. NAD+ delivered directly into the bloodstream achieves plasma concentrations orders of magnitude higher than oral supplementation — and these elevated plasma levels drive meaningful intracellular uptake. For people with significant NAD+ depletion (typically 40+, or anyone with a history of heavy alcohol use, chronic illness, or intense athletic training), IV delivery is the only method that reliably produces noticeable subjective effects.
NAD+ infusions have a reputation for intensity — and that reputation is partially earned. Unlike most IV therapies that feel like nothing, high-dose NAD+ infusions produce noticeable sensations during the drip: chest tightness, a general "full" feeling, muscle fatigue, and sometimes nausea. These are normal and dose-dependent. Our physicians rate the infusion speed to match your tolerance — first sessions are slower, with speed increasing as you become accustomed.
Sessions typically run 2–4 hours depending on dosage. Most clients come prepared with a laptop, book, or podcast. The discomfort during the infusion is temporary, and it's followed by a distinctive post-infusion effect that most clients describe as mental clarity, elevated energy, and an overall sense of physiological reset. Some clients report the best sleep of their lives the night after an NAD+ infusion.
Our physician team will assess your health history and recommend the appropriate protocol — starter dose, loading protocol, or maintenance schedule — for your situation.
IV Therapy Info Call (470) 359-6195For significant NAD+ restoration, a loading protocol of 4–10 sessions over 2 weeks is standard. Maintenance is typically monthly or quarterly depending on goals. Single sessions provide real benefits but the most transformative effects come from a loading protocol.
Partially. Slowing the infusion rate reduces intensity. Taking breaks during the infusion also helps. Some clients tolerate 500mg+ at normal speed comfortably; others prefer slower 250mg sessions. Our physicians adjust based on your feedback during the session — there is no fixed protocol.
Yes — a common combination is NAD+ with a Vitamin C and glutathione push either before or after the infusion. This provides the antioxidant support to make the most of the NAD+ replenishment. Our physicians will recommend the appropriate combination for your goals.
IV infusion delivers NAD+ slowly over hours, which is better tolerated and allows higher total dosing. Subcutaneous or intramuscular NAD+ injections are faster but limited in dose. For significant restoration protocols, IV is the preferred method at THRIVE.
THRIVE Peak Performance | 3568 Old Milton Pkwy, Alpharetta, GA 30005 | Serving Alpharetta, Milton, Roswell, Johns Creek, and Cumming. Call (470) 359-6195.